Clinical Support for the BrainPath® Approach

(Published/Presented Clinical Data Last Updated 8/08/17)

Proof of Concept

  1. Labib MA, Shah M, Kassam AB, Young R, Zucker L, Maioriello A, et al. The safety and feasibility of image-guided BrainPath-mediated transsulcul hematoma evacuation: a multicenter study.  Neurosurgery.  2017; 80(4): 515-524.  http://dx.doi.org/10.1227/NEU.0000000000001316
  2. Kassam AB, Labib MA, Bafaquh M, et al. Part II: an evaluation of an integrated systems approach using diffusion-weighted, image-guided, Exoscopic-assisted, transulcal radial corridors. Innovative Neurosurg. 2015; 3(1-2): 25-33. http://dx.doi.org/10.1515/ins-2014-0012
  3. Kassam AB, Labib MA, Bafaquh M, et al. Part I: the challenge of functional preservation: an integrated systems approach using diffusion-weighted, image-guided, Exoscopic-assisted, transulcal radial corridors. Innovative Neurosurgy. 2015; 3(1-2): 5-23. http://dx.doi.org/10.1515/ins-2014-0011
  4. Labib M, Britz G, Young R, Zucker L, Shah M, Kulwin CG, et al. The safety and efficacy of image-guided trans-sulcal radial corridors for hematoma evacuation: a multicenter study.  Late breaking oral presentation LB12 at: 2015 International Stroke Conference; February 11-13, 2015; Nashville, TN. http://my.americanheart.org/idc/groups/ahamah-public/@wcm/@sop/@scon/documents/downloadable/ucm_471665.pdf
  5. Ritsma B, Kassam AB, Dowlatshahi D, Nguyen T, Stotts G. Minimally invasive subcortical parafascicular transsulcal access for clot evacuation (Mi SPACE) for intracerebral hemorrhage. Case Rep Neurol Med. 2014;2014(102307): 4 pages. http://dx.doi.org/10.1155/2014/102307

Novel Applications

  1. Witek AM, Moore NZ, Sebai MA, Bain MD. BrainPath-mediated resection of a ruptured subcortical arteriovenous malformation. Operative Neurosurgery. 2017; 0:1-7. Published Ahead of Print. http://dx.doi.org/10.1093/ons/opx186
  2. Gonen L, Chakravarthi SS, Monroy-Sosa A, Celix JM, Kojis N, Singh M, et al. Initial experience with a robotically operated video optical telescopic-microscope in cranial neurosurgery: feasibility, safety, and clinical applications. Neurosurgical Focus. 2017; 42(5): E9. https://dx.doi.org/10.3171/2017.3.FOCUS1712
  3. Somasundaram A, Evans J, Shah M, Asbari SH, Chicoine M, Kulwin C. Resection of deep-seated intrinsic brain tumors using a novel combination of a minimally invasive tubular brain retraction system, high resolution exoscope visualization, and high field intraoperative magnetic resonance imaging (iMRI).  Poster #2081 presented at: 2016 Congress of Neurological Surgeons Annual Meeting; September 24-28, 2016; San Diego, CA.  http://latebreaking16.cns.org/posterbrowser.aspx
  4. Chen CJ, Caruso J, Starke RM, et al. Endoport-assisted microsurgical treatment of a ruptured periventricular aneurysm.  Case Rep Neurol Medicine.  2016; 2016(8654262): 4 pages.  http://dx.doi.org/10.1155/2016/8654262
  5. Habboub G, Sharma M, Barnett GH, Mohammadi AM. A novel combination of two minimally invasive surgical techniques in the management of refractory radiation necrosis: Technical note.  Journal of Clinical Neuroscience. 2016; 35: 117-121.  https://dx.doi.org/10.1016/j.jocn.2016.09.020
  6. Amenta PS, Dumont AS, Medel R. Resection of a left posterolateral thalamic cavernoma with the Nico BrainPath sheath: case report, technical note, and review of the literature.  Interdisciplinary Neurosurgery: Advanced Techniques and Case Management.  2016; 5:12-17.  http://dx.doi.org/10.1016/j.inat.2016.03.006
  7. Ding D, Starke R, Crowley R, Liu K. Endoport-assisted microsurgical resection of cerebral cavernous malformations. Journal of Clinical Neuroscience. 2015; 22(6): 1025-1029. http://dx.doi.org/10.1016/j.jocn.2015.01.004

White Matter Tract Recovery

  1. Chakravarthi SS, Zbacnik A, Jennings J, et al. White matter tract recovery following medial temporal lobectomy and selective amygdalophippocampectomy for tumor resection via a ROVOT-m port-guided technique: A case report and review of literature.  Interdisciplinary Neurosurgery. 2016; 6:55-61.  http://dx.doi.org/10.1016/j.inat.2016.07.004
  2. Zucker, L. Corticospinal tract restoration post parafascicular transulcal subcortical (thalamic) ICH evacuation.  Poster #1450 presented at: 2016 Congress of Neurological Surgeons Annual Meeting; September 24-28, 2016; San Diego, CA.  http://2016.cns.org/posterbrowser.aspx

Vascular Clinical Data

Minimally Invasive Parafascicular Surgery for Intracerebral Hemorrhage

  1. Sujijantara N, El Tecle N, Pierson M, Urquiaga JF, Quadri NF, Ashour AM, et al. Trans-sulcal endoportassisted evacuation of supratentorial intracerebral hemorrhage: initial single-institution experience compared to matched medically managed patients and effect on 30-day mortality. Operative Neurosurgery. 2017; 0:1-8. Published Ahead of Print. https://doi.org/10.1093/ons/opx161
  2. Lang M, Witek AM, Moore NZ, Bain MD. Clinical Outcomes of Patients Undergoing BrainPath-assisted Evacuation of Intracerebral Hemorrhage.  Abstract presented at: 2017 International Stroke Conference; February 22-24, 2017; Houston, TX.  https://aha.scientificposters.com/epsAbstractAHA.cfm?id=1
  3. Bauer AM, Rasmussen PA, Bain MD. Initial single-center technical experience with the BrainPath system for acute intracerebral hemorrhage evacuation.  Operative Neurosurgery.  2016; 0:1-7.  Published Ahead of Print.  http://journals.lww.com/onsonline/pages/articleviewer.aspx?year=9000&issue=00000&article=99972&type=abstract
  4. Przybylowski CJ, Ding D, Starke RM, Crowley RW, Liu KC. Endoport-assisted surgery for the management of spontaneous intracerebral hemorrhage. Journal of Clinical Neuroscience. 2015; 22(11): 1727-1732. http://dx.doi.org/10.1016/j.jocn.2015.05.015
  5. Ding D, Przybylowski CJ, Starke, RM, et al. A minimally invasive anterior skull base approach for evacuation of a basal ganglia hemorrhage. Journal of Clinical Neuroscience. 2015; 22(11): 1816-1819. http://dx.doi.org/10.1016/j.jocn.2015.03.052
  6. Chen J, Tran K, Dastur C, Stradling D, Yu W. The use of the BrainPath stereotactic guided surgery for the removal of spontaneous intracerebral hemorrhage: a single institutional experience.  Abstract presented at: 2015 NeuroCritical Care Society Meeting; October 7-10, 2015; Scottsdale, AZ.  http://link.springer.com/article/10.1007/s12028-015-0193-y
  7. Kulwin C, Rodgers R, Shah M. Preliminary experience with evacuation of intracerebral hemorrhage via a minimally invasive parafascicular technique.  Presented at: 2015 Neurosurgical Society of America Annual Meeting; April 2015.
  8. Britz G, Kassam AB, Labib M, Young R, Zucker L, Maioriello A, et al. Minimally invasive subcortical parafascicular access for clot evacuation: a paradigm shift.  Poster # MP120 presented at: 2015 International Stroke Conference; February 11-13, 2015; Nashville, TN.  http://stroke.ahajournals.org/content/46/Suppl_1/AWMP120.short?rss=1
  9. Ghinda DC, Bafaquh M, Labib M, Kumar R, Agbi CB, Kassam AB. A Transulcul Exoscopic radial corridor approach for the management of primary intracranial hemorrhage.  Poster #1621 presented at: 2013 Congress of Neurological Surgeons Annual Meeting; October 19-23, 2013; San Francisco, CA. http://2013.cns.org/posterbrowser.aspx.

Minimally Invasive Parafascicular Surgery for Traumatic Intracerebral Hemorrhage

  1. Chen JW, Paff MR, Abrams-Alexandru D, Kaloostian SW. Decreasing the cerebral edema associated with traumatic intracerebral hemorrhages: use of a minimally invasive technique.  In: RL Applegate et al (eds), Brain Edema XVI: Translate Basic Science into Clinical Practice, Acta Neurochirurgica Supplement. 2016; 121:279-284.  doi: 10.1007/978-3-319-18497-5_48.  https://www.ncbi.nlm.nih.gov/pubmed/26463961
  2. Chen J, Kaloostian SW. Use of minimally invasive techniques under austere circumstances for the urgent resection of subcortical intracerebral hemorrhages.  Poster #0075 presented at: 12th Annual Conference of the Society for Brain Mapping and Therapeutics; March 6-8, 2015.

Tumor Clinical Data

Minimally Invasive Parafascicular Surgery for Tumors, Cysts, and Lesions

  1. Chen Y, Omay SB, Sathwik SR, Liang B, Almeida JP, Ruiz-Trevino AS, et al. Transtubular excisional biopsy as a rescue for a non-diagnostic stereotactic needle biopsy – case report and literature review. Acta Neurochir. 2017; 0:1-7. Published Ahead of Print. https://dx.doi.org/10.1007/s00701-017-3260-7
  2. Jackson C, Gallia GL, Chaichana KL. Minimally invasive biopsies of deep-seated brain lesions using tubular retractors under exoscopic visualization. Journal of Neurological Surgery, A. 2017; Ahead of Print. https://doi.org/10.1055/s-0037-1602698
  3. Scranton RA, Fung SH, Britz GW. Transulcal parafascicular minimally invasive approach to deep and subcortical cavernomas: technical note.  Journal of Neurological Surgery. 2016; 125(6): 1360-1366.  http://dx.doi.org/10.3171/2015.12.JNS152185
  4. Nagatani K, Takeuchi S, Feng D, Mori K, Day JD. High definition exoscope system for microneurosurgery: Use of an exoscope in combination with tubular retraction and frameless neuronavigation for microsurgical resection of deep brain lesions. Neurological Surgery, Japan. 2015; 43(7): 611-617. ISID:1436203086. http://medicalfinder.jp/doi/abs/10.11477/mf.1436203086
  5. Labib M, Young RL, Rovin RA, Day JD, Eliyas JK, Bailes JE. The safety and efficacy of diffusion tensor imaging (DTI)- guided Transulcal radial tubular corridors to subcortical neoplasms: A multicenter study.  Abstract presented at: 2015 Congress of Neurological Surgeons Annual Meeting; September 26-30, 2015; New Orleans, LA.  http://2015.cns.org/posterbrowser.aspx
  6. Eliyas JK, Bailes J. Early experience with trans-sulcal parafascicular Exoscopic resection of supratentorial brain tumors.  Neuro Oncol (2014) 16 (suppl 5):v161.  doi: 1093/neuonc/nou265.13.  
  7. Kulwin CG, Shah MV. Minimally invasive parafascicular approach to deep cerebral lesions: initial Indiana University experience.  Presented at: 2014 Neurosurgical Society of America Annual Meeting; June 2014.
  8. Rovin R, Kassam AB. Minimally invasive surgical resection of subcortical tumors using the six pillars system.  Poster #ST-029 presented at: 18th Annual Meeting of the Society for Neuro-Oncology; November 21-24, 2013; San Francisco, CA. http://soc-neuro-onc.conference-services.net/reports/template/onetextabstract.xml?xsl=template/onetextabstract.xsl&conferenceID=3676&abstractID=760212.
  9. Labib M, Ghinda D, Bafaquh M, Kumar R, Agbi C, Kassam AB. The diffusion tensor imaging (DTI) guided Transulcul Exoscopic radial corridor approach for the resection of lesions in the sensorimotor area.  Poster #1598 presented at: 2013 Congress of Neurological Surgeons Annual Meeting; October 19-23, 2013; San Francisco, CA.  http://2013.cns.org/posterbrowser.aspx.

Minimally Invasive Parafascicular Surgery for Intraventricular Tumors, Cysts, and Lesions

  1. Eliyas JK, Glynn R, Kulwin CG, et al. Minimally-invasive trans-sulcal resection of Intra-ventricular and Peri-ventricular lesions through a tubular retractor system: Multi-centric experience and results.  World Neurosurgery.  2016; 90: 556-564.  http://dx.doi.org/10.1016/j.wneu.2015.12.100
  2. Alzate J, Young R, Rovin R. A novel minimally invasive approach for the resection of intraventricular tumors.  Neuro Oncol (2014) 16 (suppl 5):v127.  doi: 1093/neuonc/nou260.3.

Comparisons and Reviews

  1. Ziai W, Nyquist P, Hanley DF. Surgical strategies for spontaneous intracerebral hemorrhage.  Seminars in Neurology. 2016;36:261-268.  http://dx.doi.org/10.1055/s-0036-1582131
  2. Fiorella D, Arthur A, Bain M, Mocco J. Minimally invasive surgery for intracerebral and intraventricular hemorrhage. Stroke. 2016;47:1399-1406. http://dx.doi.org/10.1161/STROKEAHA.115.011415

Tissue Preservation System Methodology

  1. Cartwright M. Towards the Development of Personalized Medicine: A Novel Tissue Preservation System for the Automation and Standardization of Brain Tumor Harvesting in a Surgical Setting. FASEB Journal. 2017: 31(1): supplement lb516. http://www.fasebj.org/content/31/1_Supplement/lb516.abstract?sid=94be4899-a0b2-491e-89e1-5189dbe511f5
  2. Kumar R, Gont A, Hanson JEL, Cheung AYL, Nicholas G, Woulfe J, et al. Isolating glioblastoma tumor initiating progenitor cells from the subventricular zone using a novel minimally invasive approach.  Neuro Oncol (2014) 16 (suppl 5):v200.  http://doi.org/10.1093/neuonc/nou275.15

Economic Analyses

  1. Norton SP, Dickerson EM, Kulwin CG, Shah MV. Technology that achieves the Triple Aim: an economic analysis of the BrainPath approach in neurosurgery. ClinicoEconomics and Outcomes Research. 2017;9: 519-523. https://doi.org/10.2147/CEOR.S133623